. Author manuscript; available in PMC: 2018 Jan 1.

Published in final edited form as: Nat Genet. 2017 May 22;49(7):1113–1119. doi: 10.1038/ng.3874

Table 1. Newly identified CAD-associated genomic regions.

CAD-association results for the lead SNPs from the European and the all ancestry meta-analyses are reported. Note, SNP allele frequencies for each ancestry are provided in, Supplementary Table 5 and in Supplementary Fig. 3 for each of the studies with de novo genotyping.

Closest gene(s)	Variant/alleles	Chr:Position (EA AF)	European				All Ancestries

			OR	[95% CI]	P	N	OR	[95%CI]	P	log₁₀BF	N
ATP1B1	rs1892094C>T	1:169094459 (T 0.50)	0.96	[0.94-0.97]	3.99x10^-8	217,782	0.96	[0.94-0.97]	2.25x10-8	6.33	243,623
DX59/CAMSAP2	rs6700559C>T	1:200646073 (T 0.47)	0.96	[0.94-0.97]	2.50x10^-8	221,073	0.96	[0.95-0.97]	1.13x10^-8	6.68	246,913
LMOD1	rs2820315C>T	1:201872264 (T 0.30)	1.05	[1.03-1.07]	4.14x10^-9	214,844	1.05	[1.03-1.07]	7.70x10^-10	7.72	240,685
TNS1^a	rs2571445G>A	2:218683154 (A 0.39)	1.04	[1.02-1.06]	3.58x10^-6	194,254	1.05	[1.03-1.06]	4.55x10^-10	8.41	220,047
ARHGAP26	rs246600C>T	5:142516897 (T 0.48)	1.05	[1.03-1.06]	1.29x10^-8	210,380	1.04	[1.03-1.06]	1.51x10^-8	6.39	236,223
PARP12	rs10237377G>T	7:139757136 (T 0.35)	0.95	[0.93-0.97]	1.70x10^-7	181,559	0.95	[0.93-0.97]	1.75x10^-8	6.32	207,399
PCNX3	rs12801636G>A	11:65391317 (A 0.23)	0.95	[0.93-0.97]	1.00x10^-7	211,152	0.95	[0.94-0.97]	9.71x10^-9	6.64	236,985
SERPINH1	rs590121G>T	11:75274150 (T 0.30)	1.05	[1.03-1.07]	1.54x10^-8	207,426	1.04	[1.03-1.06]	9.32x10^-8	5.80	233,249
C12orf43/HNF1A	rs2258287C>A	12:121454313 (A 0.34)	1.05	[1.03-1.06]	6.00x10^-9	221,068	1.04	[1.03-1.06]	2.18x10^-8	6.40	246,901
SCARB1	rs11057830G>A	12:125307053 (A 0.16)	1.07	[1.05-1.10]	5.65x10^-9	177,550	1.06	[1.04-1.09]	1.34x10^-8	6.49	203,394
OAZ2, RBPMS2	rs6494488A>G	15:65024204 (G 0.18)	0.95	[0.93-0.97]	1.43x10^-6	205,410	0.95	[0.93-0.97]	2.09x10^-8	6.41	228,578
DHX38	rs1050362C>A	16:72130815 (A 0.38)	1.04	[1.03-1.06]	2.32x10^-7	216,025	1.04	[1.03-1.06]	3.52x10^-8	6.16	241,858
GOSR2	rs17608766T>C	17:45013271 (C 0.14)	1.07	[1.04-1.09]	4.14x10^-8	215,857	1.06	[1.04-1.09]	2.10x10^-7	5.30	231,213
PECAM1	rs1867624T>C	17:62387091 (C 0.39)	0.96	[0.94-0.97]	1.14x10^-7	220,831	0.96	[0.95-0.97]	3.98x10^-8	6.03	246,674
PROCR^a	rs867186A>G	20:33764554 (G 0.11)	0.93	[0.91-0.96]	1.26x10^-8	213,505	0.93	[0.91-0.96]	2.70x10^-9	7.11	239,340

These are nonsynonymous SNPs.

EA, Effect allele. AF, Effect allele frequency in Europeans. N, Number of individuals in the analysis. Log₁₀BF, log base 10 of the Bayes factor obtained from the MANTRA analyses (log₁₀BF>6 is considered significant). There was no convincing evidence of heterogeneity at the new CAD-associated SNPs, P_het ≥ 0.01. P-value for heterogeneity across meta-analysed datasets are provided in Supplementary Table 4 and I² statistics in Supplementary Fig. 3.