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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Chem Res Toxicol. 2015 Jun 8;28(7):1398–1408. doi: 10.1021/acs.chemrestox.5b00015

Figure 1.

Figure 1

Prophylactically administered NaNO2 ameliorates NaHS toxicity in mature and juvenile mice. (A) Injection paradigm. (B) Mice (Swiss Webster males, 16–18 weeks of age) were given NaHS in saline (16 mg/kg, ip), and times until death were recorded. The duration of survival (breathing cessation) was measured from the time of the sulfide injection (t = 0). Survival quotients are shown with surviving mice/total mice written above the bar. NaNO2 (12 or 24 mg/kg, ip) was given 5 min prior to NaHS injection. Supplemental oxygen (100% O2) was administered for either 15 min or until death immediately after NaHS injections (* p ≤ 0.05 vs NaHS injection alone). (C) Juvenile mice (Swiss Webster males, 6–8 weeks old) were injected (ip) with either 16, 18, or 20 mg/kg NaHS, and survival was recorded as for adults. In addition, 24 mg/kg NaNO2 was given 5 min before 18 mg/kg NaHS (* p ≤ 0.05 vs 18 mg/kg NaHS injection).