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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Chem Res Toxicol. 2015 Jun 8;28(7):1398–1408. doi: 10.1021/acs.chemrestox.5b00015

Figure 2.

Figure 2

RotaRod testing of neuromuscular coordination following NaHS/NaCN/NaNO2 exposures in adult Swiss Webster mice. (A) RotaRod testing paradigm: arrows indicate RotaRod testing times; lines with bars indicate injection times (all ip). Mice were trained on the RotaRod 24 h before injection, and a baseline performance was obtained 1 h before injection (Preip). Mice were tested every 15 min after injections for 1 h to assess recovery. (B) Comparison of performance for injections of 16 mg/kg NaHS (●), 24 mg/kg, NaNO2 (□) and 24 mg/kg NaNO2 injected 5 min prior to 16 mg/kg NaHS dose (▲). (C) Comparison of performance for injections of 16 mg/kg NaHS (●), 6.4 mg/kg NaCN (◆), or 24 mg/kg NaNO2 injected 5 min prior to 6.4 mg/kg NaCN (□). Numbers of animals (in parentheses) used in each set of experiments: NaHS (6), NaNO2 (8), NaNO2 + NaHS, (8), NaCN (9), NaNO2 + NaCN (10). (*, p ≤ 0.05 vs controls.)