Table 1. Evaluation of preparation procedures for blank HDL-mimicking nanoparticle formation.
| Preparation conditions | Particle size (nm) | P.I. |
|---|---|---|
| 50°C water + 30 min stirring at 50°C | 347.7 ± 19.4 | 0.322 ± 0.0075 |
| 50°C water + 30 min stirring at RT | 297.7 ± 21.5 | 0.296 ± 0.0118 |
| RT water + 30 min stirring at RT | 335.4 ± 18.7 | 0.320 ± 0.0125 |
| 50°C water + 5 min homogenization | 183.9 ± 7.0 | 0.276 ± 0.030 |
a
The data are presented as the mean of the mean particle size of NPs in different batches ± standard deviation (SD) (n=3).
b
P.I. means polydispersity index that indicates size distribution of NPs. When P.I. < 0.35, NPs present as one single peak in the measurement (n=3).