Table 6.
Mean Values at Baseline and 8 Years and Changes in Anthropometric, Metabolic, and Hormonal Parameters From Baseline to 8 Years in Matched, Treated, and Untreated Groups as Analyzed by the Propensity Method.a
| Matched Group Treated (n = 82) | P Value From Baseline | Matched Group Untreated (n = 82) | P Value From Baseline | Estimated Adjusted Difference Between Groups at 8 Years | P Value Between Groups | |||
|---|---|---|---|---|---|---|---|---|
| Baseline | Year 8 | Baseline | Year 8 | |||||
| Anthropometry | ||||||||
| Weight, kg | 96.7 (15.8) | 83.2 (8.4) | <.0001 | 93.9 (9.4) | 95.1 (7.8) | NS | −18.9 | <.0001 |
| BMI, kg/m2 | 30.7 (4.9) | 26.6 (2.6) | <.0001 | 30.5 (3.3) | 31.0 (3.0) | NS | −6.0 | <.0001 |
| Waist circumference, cm | 106.1 (9.2) | 98.3 (6.0) | <.0001 | 106.0 (6.7) | 107.7 (5.7) | <.01 | −11.1 | <.0001 |
| Glycemic control | ||||||||
| Fasting glucose, mmol/L | 5.8 (0.9) | 5.2 (0.1) | <.0001 | 5.5 (0.4) | 5.5 (0.4) | NS | −0.4 | <.0001 |
| HbA1c, % | 7.1 (1.3) | 5.5 (0.4) | <.0001 | 6.0 (1.2) | 6.4 (1.5) | <.0005 | −1.8 | <.0001 |
| Other metabolic parameters | ||||||||
| Total cholesterol, mmol/L | 7.2 (1.2) | 4.8 (0.2) | <.0001 | 6.6 (1.2) | 7.0 (1.1) | <.005 | −2.6 | <.0001 |
| HDL cholesterol, mmol/L | 1.3 (0.5) | 1.9 (0.4) | <.0001 | 1.2 (0.5) | 1.2 (0.7) | <.005 | 0.5 | <.0001 |
| LDL cholesterol, mmol/L | 4.2 (1.0) | 2.7 (0.7) | <.0001 | 3.8 (1.6) | 4.3 (1.3) | <.0001 | −1.8 | <.0001 |
| Triglycerides, mmol/L | 3.1 (0.6) | 2.1 (0.1) | <.0001 | 3.0 (0.6) | 3.3 (0.6) | <.005 | −1.1 | <.0001 |
| Total cholesterol: HDL ratio | 6.1 (2.3) | 2.7 (0.7) | <.0001 | 6.9 (3.4) | 7.3 (3.4) | NS | −4.2 | <.0001 |
| Non-HDL cholesterol, mmol/L | 5.8 (0.9) | 2.9 (0.4) | <.0001 | 5.4 (1.3) | 5.8 (1.4) | NS | −3.1 | <.0001 |
| Systolic blood pressure, mm Hg | 150.6 (16.5) | 129.7 (6.8) | <.0001 | 138.7 (15.5) | 135.8 (5.7) | <.05 | −24.3 | <.0001 |
| Diastolic blood pressure, mm Hg | 90.6 (10.2) | 74.4 (4.5) | <.0001 | 79.0 (8.6) | 76.0 (4.4) | NS | −16.0 | <.0001 |
| Heart rate, bpm | 77.6 (3.5) | 72.1 (1.5) | <.0001 | 75.7 (5.3) | 77.8 (5.1) | <.05 | −6.3 | <.0001 |
| Pulse pressure, mmHg | 60.0 (8.5) | 55.4 (5.1) | <.0001 | 59.7 (10.4) | 59.8 (4.0) | NS | −8.1 | <.0001 |
| Rate pressure product | 11 703 (1471) | 11 703 (1471) | <.0001 | 10 500 (1450) | 10 567 (865) | <.005 | −2654 | <.0001 |
| Liver transaminases | ||||||||
| AST, U/L | 44.4 (19.0) | 16.7 (3.0) | <.0001 | 23.2 (5.0) | 40.4 (8.7) | <.0001 | −27.4 | <.0001 |
| ALT, U/L | 47.7 (20.4) | 16.5 (3.1) | <.0001 | 27.1 (5.1) | 44.4 (8.4) | <.0001 | −31.4 | <.0001 |
| Total testosterone, nmol/L | 9.6 (1.4) | 16.6 (1.9) | <.0001 | 9.6 (1.1) | 8.8 (1.6) | <.05 | 7.0 | <.0001 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NS, not significant; SD, standard deviation.
aData are shown as means (SD).