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. 2017 Jun 15;7(8):2545–2558. doi: 10.1534/g3.117.042234

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Copyright © 2017 Ferland et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Interaction between Szs1/GST1 and Esf1/retest GST. (A) BXD strains were sorted according to their genotype for rs8259388 within the Szs1 locus and rs13478053 within Esf1 to compare their effects on their respective phenotypes. Significant differences in response between the groups are indicated by an asterisk. (B) The Szs1 subgroups were further divided according to their Esf1 genotype to compare the average retest GST in these four groups. Significant differences (P < 0.05 marked by an asterisk) in retest GST were seen between B6 and D2 mice carrying the D2 allele of Szs1, but not the B6 allele. (C) Similar sorting for the two loci was performed in a [B6×D2] F2 intercross to reveal a similar pattern of significance between B6 and D2 homozygous animals, but not heterozygotes.