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. 2017 Jun 9;7(8):2595–2604. doi: 10.1534/g3.117.043828

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Copyright © 2017 Lam et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MHC-wide gene expression patterns defined by MHC haplotypes. (A) Hierarchical and PC analysis based on expression of 177 MHC-residing loci found within chr6:29.0–33.2 Mb. (B) Hierarchical and PC analysis based on expression of genes in the human genome. Expression profiles were derived from RNA-sequencing of eight B-LCLs with two libraries generated per B-LCL. Blue indicates B-LCLs carrying the A2-B46-DR9 haplotype, red indicates B-LCLs carrying the A33-B58-DR3 haplotype, and green indicates B-LCLs carrying the A1-B8-DR3 haplotype. B-LCL, B-lymphoblastoid cell line; chr, chromosome; MHC, major histocompatibility complex; PC, principal component.