Mean ± SEM of the ratio of low cSOD: high cSOD activity viability (frequency) for adult male and female flies across the eight DGRPi genetic backgrounds. Values closer to 1 indicate more similar viabilities at the levels of cSOD activity being compared; C.I.s are at 95% and represent the ratio of the low cSOD activity and high cSOD activity SEMs. (A) 0% cSOD activity: 50% cSOD activity: Female: lowest ratio 705, 0.168 < 0.344 < 0.532; highest ratio 335, 0.538 < 0.819 < 1.12: Male: lowest ratio 313, 0.147 < 0.498 < 1.28; highest ratio 335, 0.575 < 0.781 < 1.05 (B) 30% cSOD activity: 80% cSOD activity, Female: lowest ratio 820, 0.309 < 0.586 < 0.979; highest ratio 335, 0.699 < 1.04 < 1.74: Male: lowest ratio 304, 0.0162 < 0.492 < 0.974; highest ratio 335, 0.720 < 0.902 < 1.08. ANOVA was used to test the factor effects with an α of 0.05. Partial eta squared (ηp2) was calculated to quantify the effect of each factor. (A) cSOD activity, F1,143 = 106.7, P < 0.0001, ηp2 = 0.427. (B) cSOD activity, F1,148 = 11.2, P = 0.001, ηp2 = 0.0704. cSOD, cytosolic copper/zinc superoxide dismutase.