Figure 1.

Pedigree of Malinois dogs used for genetic mapping of the disease loci, modified from Mauri et al. (2017). Filled symbols represent animals with cerebellar dysfunction. Numbers indicate dogs from which samples were available. Six dogs affected by SDCA1 (KCNJ10:c.986T>C) are indicated by red contours. Four affected siblings from family 6, which did not carry the previously identified KCNJ10 variant, are indicated by blue contours and were selected for homozygosity mapping in this study. The affected animals MA142 and MA143 from family 5 seem to have yet another genetic form of cerebellar dysfunction (see Results and Discussion). Crosses intersecting the connection lines to the common ancestor represent the numbers of generations (e.g., MA302 is a great-grandson of the common ancestor).