Table 1.
The Characteristics of Studies in Meta- Analysis (n=19)
| Study (year) | Country | Number of patients (N) | Tumor type of salivary gland | Method of detection of EBV | Number of EBV+ patients (N) |
|---|---|---|---|---|---|
| Hamilton-dutoit (1991) | Denmark | 13 | Lymphoepithelial carcinomas | ISH | 11 |
| Lanier (1991) | Alaska | 6 | Lymphoepithelial carcinoma | ISH | 6 |
| Taira (1992) | Japan | 5 | Mucoepidermoid carcinomas | PCR | 3 |
| Gallo (1994) | Italy | 7 | Undifferentiated carcinomas | ISH | 3 |
| Leung (1995) | China | 10 | Lymphoepithelial carcinomas | ISH | 10 |
| Nagao (1996) | Japan | 5 | Undifferentiated carcinoma with lymphoid stroma | ISH | 5 |
| Tsai (1996) | Taiwan | 56 | Mucoepidermoid carcinomas: 14; Adenoid cystic carcinomas: 13; Malignant mixed tumors: 7; Adenocarcinomas: 4; Salivary duct carcinomas: 4; Acinic cell carcinomas: 2; Undifferentiated carcinomas without lymphoid stroma: 2; Lymphoepithelioma-like carcinomas: 7; Squamous cell carcinomas: 2; Small cell carcinoma: 1 | ISH | 7 |
| Wen (1997) | Japan | 80 | Undifferentiated carcinomas: 6; T-cell lymphomas: 3; B-cell lymphomas: 3; Mucoepidermoid carcinomas: 15; Adenoid cystic carcinomas: 20; Acinic cell carcinomas: 15; Carcinomas in pleomorphic adenoma: 8; Adenocarcinoma: 5; Squamous cell carcinomas: 3; Papilloadenocarcinomas: 2 | ISH | 9 |
| Lin (1997) | China | 18 | Lymphoepithelial carcinomas | PCR/ISH* | 18 |
| Wolvius (1997) | Netherlands | 18 | B-cell lymphoma | ISH | 0 |
| Ioachim (1998) | USA | 6 | B-cell lymphoma | ISH | 3 |
| Atula (1998) | Finland | 19 | Acinic cell carcinomas: 4; Lymphomas: 4; Squamous cell carcinomas: 3; Mucoepidermoid carcinomas: 3; Adenocarcinomas: 2; Adenoid cystic carcinoma:1; Epithelial-myoepithelial carcinoma:1; Myoepithelial carcinoma: 1 | PCR/ISH* | 1/0 |
| Kim (1999) | Korea | 28 | Mucoepidermoid carcinoma: 13; Adenoid cystic carcinoma: 8; Malignant mixed tumor: 2; Acinic cell carcinoma: 2; Cystadenocarcinoma: 1; Poorly differentiated carcinoma: 1; Lymphoepithelial carcinoma: 1 | ISH | 1 |
| Pollock (1999) | Ireland | 13 | Mucoepidermoid carcinoma: 2; Salivary duct carcinoma: 2; Non-Hodgkin’s lymphoma: 2; Acinic cell carcinoma: 2; Adenocarcinoma arising in PSA: 2; Polymorphous low grade adenocarcinoma: 1; Undifferentiated carcinoma: 1; Epithelial-myoepithelial carcinoma: 1 | ISH | 0 |
| Venkateswaran (2000) | USA | 13 | Mucoepidermoid carcinoma: 7; Rhabdomyosarcoma: 3; Acinic cell carcinoma: 2; Malignant fibrous histiocytoma: 1 | ISH | 0 |
| Wu (2004a) | China | 14 | Lymphoepithelial carcinomas | PCR/ISH* | 12/14 |
| Wu (2004b) | China | 16 | lymphoepithelial carcinomas | ISH | 16 |
| Zhao (2014) | China | 21 | Primary lymphoepithelioma-like carcinomas | ISH | 21 |
| Hühns (2015) | Germany | 93 | Mucoepidermoid carcinoma: 17; Adenoid cystic carcinoma: 16; Adenocarcinoma NOS: 10; Salivary duct carcinoma: 9; Acinus cell carcinoma: 7; Adenoid basal-cell carcinoma: 5; Squamous cell carcinoma: 5; Nonkeratinized squamous cell carcinoma: 4; Keratinized squamous cell carcinoma: 4; Oncocytic carcinoma: 2; Lymphoepithelial carcinoma: 2; Micropapillary carcinoma: 2; Myoepithelial carcinoma: 5; Pseudo sarcomatoid carcinoma: 1; Polymorphic low-grade carcinoma: 1; Undifferentiated carcinoma: 1; Cystadenocarcinoma: 1; Malignant melanoma: 1 | ISH | 1 |
ISH, in situ hybridization; NOS, not otherwise specified; PCR, polymerase chain reaction.
*
in two methods, we used the number of the most detection of EBV in meta-analysis.