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. Author manuscript; available in PMC: 2017 Aug 14.
Published in final edited form as: Biochemistry. 2016 Mar 16;55(12):1749–1757. doi: 10.1021/acs.biochem.6b00026

Figure 2.

Figure 2

Peg2 forms DNA/PNA heteroquadruplexes with long loop-containing DNA G-quadruplexes. (A) CD spectra of each Peg2/DNA complex in 100 mM K+ suggests overall more parallel topology (min at 240 nm, max at 260 nm) than those of the DNA alone (Figure 1A). (B) TD spectroscopy in 100 mM K+ detects G-quadruplex formation for each complex as evidenced by the inversion near 295 nm. The inset graph highlights the region around 295 nm.