Skip to main content
. Author manuscript; available in PMC: 2018 Jun 29.
Published in final edited form as: Cell. 2017 Jun 29;170(1):17–33. doi: 10.1016/j.cell.2017.06.009

Figure 1. Conformational Changes in Switch Regions when RAS Transitions from Inactive GDP-Bound State to Active GTP-Bound State.

Figure 1

Switch I and switch II regions are colored blue and violet, respectively, and side chain atoms of residues that undergo large conformation changes during transition are shown in stick representation. Interactions formed by γ-phosphate and magnesium ions are shown using dashed lines. HRAS.GDP and HRAS.GppNHp are from PDB: 4Q21 and 5P21, respectively. RAS is activated by GDP/GTP exchange stimulated by GEFs and inactivated by GTP hydrolysis stimulated by GAPs.