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. Author manuscript; available in PMC: 2018 Jun 29.
Published in final edited form as: Cell. 2017 Jun 29;170(1):17–33. doi: 10.1016/j.cell.2017.06.009

Figure 7. KRAS Residues with Higher Mutational Frequency in Cancer.

Figure 7

(A) KRAS residues with more than 10 mutations in cBioPortal database for cancer genomics are shown along with number of mutations (in a total of 1845 mutation) in parenthesis. All these residues are in the switch regions or in the G1-G5 sequence motifs that play a critical role in recognition and binding of guanine nucleotide. (B) Position of KRAS residues (shown in green color) with more than 10 mutations in cBioPortal database are mapped on the tertiary structure of KRAS.GDP (PDB: 4EPV).