Table 1.
Frequency of Mutation in RAS Isoforms and Related Proteins in Selected Human Cancers.
| Tissue | KRAS (%) | NRAS (%) | HRAS (%) | RITI (%) | NFI (%) | SPRED1 (%) | SOS1 (%) |
|---|---|---|---|---|---|---|---|
| Pancreas | 91 | 0 | <1 | <1 | 2 | <1 | <1 |
| Colon | 42 | 9 | 0 | <1 | 4 | 3 | 3 |
| Lung | 33 | <1 | <1 | 2 | 12 | 1 | 3 |
| Skin (melanoma) | 2 | 27 | 1 | 1 | 13 | 2 | 3 |
| Endometrium | 21 | 4 | <1 | 1 | 8 | 1 | 5 |
| Testicular germ cell | 13 | 5 | <1 | 0 | 2 | 0 | 1 |
| Bone marrow | 4 | 8 | 0 | <1 | 1 | 0 | <1 |
| Thyroid | 1 | 8 | 3 | 0 | <1 | 0 | <1 |
| Thymus | <1 | 2 | 8 | 0 | 2 | 0 | 0 |
| Stomach | 9 | 1 | <1 | 0 | 8 | 3 | 3 |
| Adrenal glands | 0 | 0 | 10 | 0 | 8 | 0 | 0 |
| Bladder | 0 | 1 | 5 | 1 | 8 | 1 | 3 |
| Brain | 1 | 1 | 0 | 0 | 14 | 0 | 0 |
| Cervix | 6 | <1 | <1 | 2 | 4 | <1 | 2 |
| Bile duct | 6 | 0 | 0 | 3 | 0 | 3 | 3 |
Data were compiled from the TCGA datasets present in the cBioPortal database for cancer genomics.