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. 2017 Aug 14;12(8):e0183076. doi: 10.1371/journal.pone.0183076

Fig 4. MG132-induced Nrf2 accumulation and nuclear translocation in SH-SY5Y cells is inhibited by the expression of PINK1 G309D mutant.

Fig 4

Empty vector-transfected cells and PINK1 G309D mutant cells were treated with MG132 (1 μM) for 6 h. (A) The expression of PINK1 G309D mutant inhibited the nuclear translocation and accumulation of Nrf2 following MG132 treatment. The nucleus is depicted in blue (DAPI) and Nrf2 is presented in green (AlexaFluor488). Scale bar: 20 μm. (B) Quantification of nuclear intensity.