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. 2017 Aug 14;12(8):e0182961. doi: 10.1371/journal.pone.0182961

Fig 3. Proteasome-mediated degradation plays a role in STING reduction.

Fig 3

(A) Time course assessment of STING mRNA expression after MRC-5 cells were transfected with pcDNA3.1 (0.05μg). (B) Western blotting assessment of STING after MRC-5 cells were transfected with pcDNA3.1 (0.05μg) with treatment of Bortezomib (20 nM) or DMSO for 18h. (C)Western blotting assessment of immunoprecipitated STING with anti-ubiquitin antibody.