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. 2017 Aug 14;12(8):e0182961. doi: 10.1371/journal.pone.0182961

Fig 4. RIG-I is involved in regulating the DNA-induced STING degradation.

Fig 4

(A) Western blotting analysis of RIG-I expression after MRC-5 cells were transfected with pcDNA3.1. (B) Time course assessment of RIG-I mRNA after MRC-5 cells were transfected with pcDNA3.1 (0.05μg) for the indicated time points. (C-G) Western blotting shows a reverse correlation between STING and RIG-I under different conditions: dose (C), time (D, E), DNA types (F), and Bortezomib treatment (G). (H) Silencing RIG-I partially reverses the STING degradation. (I) qRT-PCR assessment of RIG-I expression after STING knockdown in MRC-5 cells. Asterisk (*), P <0.05.