Table 2. Altered expression of genes encoding proteins closely related to IGF1 physiology.
| Gene name | Untreated Hz (Hz. Igf+/-) vs. Controls (WT. Igf+/+) (Fold Change) |
Hz + IGF1 vs. Untreated Hz (Fold Change) |
|
|---|---|---|---|
| insulin-like growth factor 1 | Igf1 | -1.72 (p≤0.05) | 1.15 (p≤0.01) |
| insulin-like growth factor I receptor | Igf1r | 1.01 (p = 0.64) | -1.39(p≤0.01) |
| insulin-like growth factor 2 | Igf2 | -3.75 (p≤0.01) | 1.07(p = 0.48) |
| insulin-like growth factor 2 receptor | Igf2r | 1.20 (p≤0.05) | -1.31(p≤0.05) |
| insulin-like growth factor binding protein 1 | Igfbp1 | 1.00 (p = 0.95) | 1.12(p = 0.21) |
| insulin-like growth factor binding protein 2 | Igfbp2 | 1.49 (p≤0.01) | 1.09(p = 0.08) |
| insulin-like growth factor binding protein 3 | Igfbp3 | -2.25 (p≤0.01) | 1.01 (p = 0.97) |
| insulin-like growth factor binding protein 4 | Igfbp4 | -1.88 (p≤0.01) | -1.26(p≤0.05) |
| insulin-like growth factor binding protein 5 | Igfbp5 | -1.79 (p≤0.001) | -1.66(p≤0.01) |
| insulin-like growth factor binding protein 6 | Igfbp6 | -2.09(p≤0.001) | 1.96 (p≤0.01) |
| connective tissue growth factor | Ctgf | -1.65 (p≤0.001) | -1.83(p = 0.38) |
| gremlin 1 | Grem1 | -1.26(p = 0.09) | -1.02(p = 0.23) |