Table 4. Expression of genes encoding proteins involved on inflammation, extracellular matrix regulation, and in heart metabolism.
| Gene name | Untreated Hz (Hz. Igf+/-)
vs. Controls (WT. Igf+/+) (Fold Change) |
Hz + IGF1
vs. Untreated Hz (Fold Change) |
|
|---|---|---|---|
| complement component 3 | C3 | -1.06(p≤0.05) | -1.88(p = 0.06) |
| histone deacetylase 5 | Hdac5 | 1.12(p = 0.21) | -1.01(p = 0.32) |
| Angiotensinogen | Agt | -1.17(p≤0.05) | 1.04(p = 0.11) |
| chemokine (C-C motif) ligand 11 | Ccl11 (Eotaxin) | -1.00 (p = 0.99) | -1.24(p≤0.05) |
| chemokine (C-C motif) ligand 2 | Ccl2 (MCP-1) | -1.27(p≤0.05) | -1.04(p = 0.97) |
| chemokine (C-C motif) ligand 3 | Ccl3(MIP-1a) | -1.06(p = 0.21) | -1.21(p = 0.53) |
| interleukin 13 | Il13 | 1.06(p = 0.27) | -1.09(p = 0.33) |
| interleukin 13 receptor alpha 2 | Il13ra2 | -1.1 (p = 0.13) | 1.07(p = 0.42) |
| interleukin 4 receptor alpha | Il4ra | -1.2 (p = 0.15) | -1.05(p = 0.56) |
| interleukin 5 | Il5 | -1.05(p = 0.14) | -1.01(p = 0.94) |
| snail family zinc finger 1 | Snai1 | -1.28(p = 0.13) | 1.03 (p = 0.61) |
| lysyl oxidase | Lox | 1.04(p = 0.28) | 1.1(p = 0.07) |
| matrix metallopeptidase 13 | Mmp13 | -1.08(p = 0.13) | 1.13(p = 0.55) |
| matrix metallopeptidase 14 (membrane-inserted) | Mmp14 | 1.17(p = 0.39) | 1.56 (p = 0.07) |
| matrix metallopeptidase 2 | Mmp2 | 1.08(p≤0.05) | 1.09(p≤0.05) |
| matrix metallopeptidase 3 | Mmp3 | 1.11(p≤0.05) | -1.32(p≤0.05) |
| matrix metallopeptidase 8 | Mmp8 | -1.27(p≤0.001) | 1.02(p = 0.15) |
| matrix metallopeptidase 9 | Mmp9 | 1.08(p = 0.30) | -1.01(p = 0.85) |
| plasminogen activator. tissue | Plat | -1.04(p = 0.34) | 1.08 (p = 0.13) |
| plasminogen activator. urokinase | Plau | 1.03(p = 0.81) | 1.01(p = 0.88) |
| plasminogen | Plg | -1.4(p≤0.05) | -1(p = 0.63) |
| serine (or cysteine) peptidase inhibitor clade E member 1 | Serpine1 | -1.70(p≤0.01) | -1.18(p = 0.31) |
| serine (or cysteine) peptidase inhibitor clade H member 1 | Serpinh1 | 1.89(p≤0.001) | -1.07(p = 0.31) |
| tissue inhibitor of metalloproteinase 1 | Timp1 | -1.19 (p≤0.05) | -1.42(p = 0.14) |
| tissue inhibitor of metalloproteinase 2 | Timp2 | -1.73(p≤0.01) | -1.34 (p≤0.001) |
| tissue inhibitor of metalloproteinase 3 | Timp3 | -1.74(p≤0.05) | -1.36(p = 0.07) |
| tissue inhibitor of metalloproteinase 4 | Timp4 | -1.19(p = 0.20) | -1.16(p≤0.05) |
| integrin alpha 1 | Itga1 | 1.43 (p≤0.05) | -1.25(p≤0.05) |
| integrin alpha 2 | Itga2 | -1.01(p = 0.42) | -1.06(p = 0.32) |
| integrin alpha 2b | Itga2b | -1.49(p≤0.01) | 1.08(p = 0.10) |
| integrin alpha 3 | Itga3 | 1.11(p = 0.34) | 1.04(p = 0.06) |
| integrin alpha V | Itgav | 1.08(p = 0.26) | 1.09(p = 0.47) |
| integrin beta 1 (fibronectin receptor beta) | Itgb1 | 1.02(p = 0.70) | 1.09(p = 0.44) |
| integrin beta 3 | Itgb3 | 1.21(p = 0.17) | 1.03(p≤0.05) |
| integrin beta 5 | Itgb5 | 1.08(p≤0.05) | -1.42(p≤0.05) |
| integrin beta 6 | Itgb6 | 1.46(p≤0.001) | 1.19(p = 0.14) |
| integrin beta 8 | Itgb8 | 1.07(p = 0.48) | -1.02(p = 0.68) |
| ae binding protein 1 | Aebp1 | -1.2(p≤0.001) | -1.87(p = 0.07) |
| annexin A4 | Anxa4 | 1.04(p = 0.12) | -1.54(p = 0.06) |
| collagen type XI alpha 1 | Col4a1 | 1.06(p = 0.17) | -1.09(p = 0.53) |
| collagen type I alpha 1 | Col1a1 | 1.12(p = 0.27) | -1.6(p≤0.05) |
| collagen type III alpha 1 | Col3a1 | 1.06(p = 0.06) | 1.08(p = 0.31) |
| decorin | Dcn | -1.23(p≤0.01) | -1.42(p≤0.05) |
| dystrophin muscular dystrophy | Dmd | 1.17(p≤0.05) | -1.2(p≤0.05) |
| coagulation factor II (thrombin) receptor | F2r | 1.22(p = 0.43) | -1.23(p = 0.42) |
| fibronectin 1 | Fn1 | -1.81(p≤0.01) | -1.21(p = 0.07) |
| aquaporin 4 | Aqp4 | -2.53(p≤0.05) | -1.22(p≤0.05) |
| phosphoenolpyruvate carboxykinase 1 cytosolic | Pdk1 | -2.82(p≤0.01) | 2.66(p≤0.01) |