Figure 1. Between-group striatal free-water (FW) and mean diffusivity (MDT).
Color bars represent the mean difference in FW and MDT values for between-group post-hoc comparisons (i.e., cKO versus control). (A) Negative values, represented by cold (blue) colors superimposed over the b0 image of a single subject, denote a significant decrease in FW in cKO mice compared to controls in the left and right striatum. (B) Positive values, represented by warm (red) colors denote a significance increase in MDT in cKO mice compared to controls in the left and right striatum. In each panel, subject-by-subject mean FW and MDT values for the associated colored voxels are depicted by white and pink bars for control and cKO mice, respectively. Results are thresholded at P < 0.005 at the voxel level and FWER corrected at P < 0.05.