Table 1. Summary of support vector machine classification model.
Results are based on single- and multi-cluster functional connectivity mean z-score values in a training cohort of 11 cKO and 11 control mice, and evaluated in an independent testing cohort of 7 cKO and 7 control mice. AUC: receiver operating characteristic area under the curve representing sensitivity and specificity in the training cohort; Prediction: 10-fold cross validation classification accuracy in testing cohort. Common slashes separate adjacent regions that comprise a common single-cluster combination of voxels. Individual clusters within multi-cluster combinations are separated by addition signs (+).
Functional connectivity cluster(s) | AUC | Prediction |
---|---|---|
1. Somatosensory cortex | 0.86 | 71.4 |
2. Sensory-motor thalamus | 0.91 | 78.6 |
3. Superior colliculus | 0.91 | 71.4 |
4. Pons | 0.95 | 78.6 |
5. Vermis/cerebellar nuclei | 0.91 | 71.4 |
6. Anisiform lobule | 0.91 | 92.9 |
7. Thalamus | 0.91 | 85.7 |
8. Somatosensory cortex + posterior parietal assoc. | 0.83 | 64.3 |
9. Somatosensory cortex + sensory-motor thalamus | 0.82 | 78.6 |
10. Somatosensory cortex + vermis/cerebellar nuclei | 0.82 | 92.9 |
11. Somatosensory cortex + sensory-motor thalamus + vermis + vermis/cerebellar nuclei + anisiform lobule | 0.75 | 92.9 |
12. Somatosensory cortex + thalamus + superior colliculus + anisiform lobule | 0.75 | 100 |
13. Somatosensory cortex + sensory-motor thalamus + superior colliculus + anisiform lobule + vermis | 0.73 | 100 |
14. Somatosensory cortex + hypothalamus/midbrain + geniculate group + anisiform lobule + vermis | 0.74 | 100 |