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. 2017 Jul 28;9:ecurrents.outbreaks.7896c43f69838f17ce1c2c372e79d55d. [Version 1] doi: 10.1371/currents.outbreaks.7896c43f69838f17ce1c2c372e79d55d

Predicted median (90% prediction interval) serum raxibacumab concentration-time profile in humans exposed to anthrax spores, following a 40 mg/kg raxibacumab intravenous 2 h infusion dose.

Predicted median (90% prediction interval) serum raxibacumab concentration-time profile in humans exposed to anthrax spores, following a 40 mg/kg raxibacumab intravenous 2 h infusion dose. The profile is based on 200 replicate simulations using observed raxibacumab pharmacokinetics in healthy subjects. The exception was raxibacumab clearance, which was increased by the same proportion as clearance was observed to increase between healthy and anthrax infected rabbits or monkeys. The median line represents the central tendency of the results. The 90% PI provides a representation of the expected variability among subjects, with 5% of the subjects falling above and 5% falling below those bounds.

The profile is based on 200 replicate simulations using observed raxibacumab pharmacokinetics in healthy subjects. The exception was raxibacumab clearance, which was increased by the same proportion as clearance was observed to increase between healthy and anthrax infected rabbits or monkeys. The median line represents the central tendency of the results. The 90% PI provides a representation of the expected variability among subjects, with 5% of the subjects falling above and 5% falling below those bounds.