TABLE 2.
Clinicopathologic characteristics of Pennsylvania’s Pigmented Lesion Group (Penn) patients
| Characteristic | SLN-positive (n = 29) % (n) |
Clinical recurrence (n = 36) % (n) |
p value |
|---|---|---|---|
| Sex | |||
| Male | 59 (17) | 58 (21) | 0.82 |
| Female | 41 (12) | 42 (15) | |
| Age (years) | |||
| ≤50 | 62 (18) | 75 (27) | 0.26 |
| >50 | 38 (11) | 25 (9) | |
| Primary site | |||
| Axial | 48 (14) | 72 (26) | 0.07 |
| Extremity | 52 (15) | 28 (10) | |
| Breslow (mm) | |||
| 0.01–0.75 | 28 (8) | 53 (19) | 0.047 |
| ≥0.76 | 72 (21) | 47 (17) | |
| Clark level | |||
| 2–3 | 24 (7) | 75 (27) | <0.001 |
| 4–5 | 72 (21) | 25 (9) | |
| Unknown | 3 (1) | 0 (0) | |
| Ulceration | |||
| Absent | 79 (23) | 83 (30) | 0.009 |
| Present | 0 (0) | 14 (5) | |
| Unknown | 21 (6) | 3 (1) | |
| Mitoses | |||
| Absent | 7 (2) | 25 (9) | 0.029 |
| Present | 83 (24) | 75 (27) | |
| Unknown | 10 (3) | 0 (0) | |
| TIL | |||
| Absent | 24 (7) | 53 (19) | 0.016 |
| Present | 66 (19) | 47 (17) | |
| Unknown | 10 (3) | 0 (0) | |
| Regression | |||
| Absent | 72 (21) | 69 (25) | 0.57 |
| Present | 14 (4) | 22 (8) | |
| Unknown | 14 (4) | 8 (3) | |
| LVI | |||
| Absent | 69 (20) | 94 (34) | 0.013 |
| Present | 7 (2) | 0 (0) | |
| Unknown | 24 (7) | 6 (2) | |
| Microsatellites | |||
| Absent | 86 (25) | 97 (35) | 0.227 |
| Present | 7 (2) | 0 (0) | |
| Unknown | 7 (2) | 3 (1) | |
| Tumor stage | |||
| T1a | 7 (2) | 22 (8) | 0.045 |
| T1b | 83 (24) | 78 (28) | |
| Unknown | 10 (3) | 0 (0) |
SLN sentinel lymph node, TIL tumor-infiltrating lymphocytes, LVI lymphovascular invasion