TABLE 3.
Uni- and multivariable analysis of factors associated with melanoma-specific survival in the John Wayne Cancer Institute (JWCI) cohort
| Characteristic | Univariable analysis | Multivariable analysisa | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| HR | 95 % CI | p value | HR | 95 % CI | p value | |
| Sex | ||||||
| Female | Ref. | – | – | – | – | – |
| Male | 1.06 | (0.83–1.35) | 0.651 | – | – | – |
| Age (years) | ||||||
| ≤50 | Ref. | – | – | – | – | – |
| >50 | 1.35 | (1.06–1.73) | 0.016 | 1.42 | (1.11–1.81) | 0.005 |
| Primary site | ||||||
| Extremity | Ref. | – | – | Ref. | – | – |
| Axial | 1.40 | (1.08–1.81) | 0.012 | 1.42 | (1.09–1.85) | 0.009 |
| Breslow (mm) | ||||||
| ≤0.75 | Ref. | – | – | – | – | – |
| >0.75 | 1.24 | (0.98–1.57) | 0.077 | – | – | – |
| Clark level | ||||||
| 1–3 | Ref. | – | – | – | – | – |
| 4–5 | 1.08 | (0.80–1.47) | 0.62 | – | – | – |
| Unknown | 0.78 | (0.46–1.32) | 0.35 | – | – | – |
| Ulceration | ||||||
| Absent | Ref. | – | – | Ref. | – | – |
| Present | 1.79 | (1.15–2.80) | 0.011 | 1.92 | (1.22–3.01) | 0.005 |
| Unknown | 1.89 | (1.46–2.44) | <0.001 | 1.64 | (1.27–2.12) | <0.001 |
| Nodal evaluation | ||||||
| SLN | Ref. | – | – | Ref. | – | – |
| CNR | 3.42 | (1.91–6.11) | <0.001 | 3.29 | (1.83–5.93) | <0.001 |
HR hazard ratio, CI confidence interval, SLN sentinel lymph node, CNR clinical nodal recurrence
a
Multivariable analysis was performed using both continuous and categorical variables. The model using categorical variables is shown