Table 1.
Demographics
| Grade Reclassification (n= 28) | No Grade Reclassification (n = 232) | P value | |||
|---|---|---|---|---|---|
| Patient characteristics at baseline | Median | IQR | Median | IQR | |
| Age, yrs | 69 | 66 – 74 | 66 | 63 – 69 | 0.03 |
| PSA, ng/ml | 5.3 | 3.0 – 6.9 | 4.0 | 2.8 – 6.3 | 0.50 |
| PSAD, ng/ml/ml | 0.11 | 0.06 – 0.16 | 0.08 | 0.05 – 0.11 | 0.03 |
| fPCA3, ng/ml | 48.0 | 24 – 75 | 24.5 | 13.1 – 45.7 | 0.007 |
| sPCA3, ng/ml | 63.5 | 37 – 93 | 36.0 | 18 – 59 | 0.002 |
| Year of PCa diagnosis | 2006 | 2004 – 2008 | 2007 | 2005 – 2008 | 0.18 |
| Time from PCa diagnosis to fPCA3, yrs | 2 | 1–3 | 2 | 1–3 | 0.33 |
| No. of biopsies at time of fPCA3 | 2 | 1–3 | 2 | 1–3 | 0.24 |
| Risk strata, n(%)1 | |||||
| Very-low-risk | 22 (79) | 221 (95) | 0.005 | ||
| Low-risk | 6 (21) | 11 (5) | |||
| Race, n(%) | |||||
| Caucasian | 26 (93) | 223 (96) | 0.21 | ||
| African-American | 1 (3.5) | 9 (4) | |||
| Other | 1 (3.5) | 0 (0) | |||
1
Risk strata = Very low-risk (T1c, Gleason score of 6 or less, PSA<10 ng/mL, 2 or fewer positive biopsy cores with cancer, 50% or less cancer in each core, PSA density <0.15 ng/mL/g) or Low-risk (men who did not meet very low-risk criteria but are T1-T2a, Gleason score 6 or less, PSA<10 ng/mL)