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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Nat Rev Microbiol. 2017 Jun 26;15(9):559–572. doi: 10.1038/nrmicro.2017.60

Table 2.

Method Mechanism Input volume Virion co-purification
Differential ultracentrifugation Density and size 35 ml Yes
ExoQuick (SBI Biotech Inc.) Precipitation 250 μl Yes
Total EV (Invitrogen Inc.) Precipitation 250 μl Yes
PEG-2000 Precipitation 250 μl – 250 ml Yes
CD63 magnetic beads Bead-based surface marker 1 – 35 ml No
Composite magnetic beads Bead-based surface markers (n=5 markers) 100 μl – 1ml No
Size exclusion chromatography Size-bases isolation 100 μl – 35 ml Yes
Density flotation (for example, Iodixanol) Density 35 ml Yes