Table 1.
Clinical characteristics based on the macroscopic vascular lesion score.
| Total Sample | Macroscopic Vascular Lesion Score a
|
||||
|---|---|---|---|---|---|
| 0b | 1 or 2 | 1≥3 | p-value c | ||
| Sample size (n) | 62 | 29 | 20 | 13 | |
| Age at enrollment, mean (S.D.), years | 81.8 (6.1) | 80.1 (6.5) | 83.04(5.26) | 83.7 (6.2) | 0.190 |
| Age at death, mean (S.D.), years | 89.0(6.4) | 86.3 (6.3) | 90.06(5.37) | 93.3 (5.5) | 0.002 |
| Last visit to death, mean (S.D.), years | 1.8 (1.4) | 1.2 (1.3) | 1.81 (1.13) | 3.01 (1.4) | 0.001 |
| Female (%) | 33 (53.2) | 11 (37.9) | 11 (55.0) | 11 (84.6) | 0.019 |
| Education, mean (S.D.), years | 13.4 (4.0) | 13.5 (4.3) | 13.95 (3.24) | 12.2 (4.4) | 0.290 |
| Blessed score, median (range) | 2.3 (2.5) | 1.5 (2.06) | 3.0 (2.09) | 3.3 (3.6) | 0.014 |
| Pathological lesions (%) | |||||
| Large Infarcts | |||||
| 1 | 8(12.9) | - | 5 (25.0) | 3 (23.1) | - |
| ≥2 | 8 (12.9) | - | 2 (10.0) | 6 (46.1) | |
| Lacunes | |||||
| 1 | 6 (9.6) | - | 2 (10.0) | 4 (30.7) | - |
| ≥2 | 6 (9.6) | - | 1 (5.0) | 5 (38.4) | |
| Leukoencephalopathy | |||||
| Mild | 12 (19.3) | - | 8 (40.0) | 4 (30.7) | - |
| Mod-severe | 11 (17.7) | - | 2 (10.0) | 9 (69.2) | - |
| Microinfarcts | 19 (30.6) | 4 (13.7) | 7 (35.0) | 8 (61.5) | 0.007 |
| Braak NFT stage, mean (S.D.) | 3.2 (1.3) | 2.2 (1.3) | 3.7 (1.2) | 3.4 (1.1) | 0.015 |
| Cortical Lewy bodies (%) | 4 (6.4) | 2 (6.9) | 0 (0) | 2 (15.3) | 0.187 |
a
Macroscopic vascular lesions score ranging 0–6.
b
Defined as absence of any macroscopic vascular lesions such as large infarcts, lacunar infarct, or leukoencephalopathy.
c
Using ANOVA for continuous variables, and Chi-square test for categorical variables.