Table 2.

Association of brain pathology with rate of change in Global Cognitive Function (BIMC)

Difference in Annual Rate of Cognitive Changea	Model 1			Model 2			Model 3
	BIMC change/yr	SE	P	BIMC change/yr	SE	p	BIMC change/yr	SE	p
MVL=(1–2) vs. MVL=0	0.49	0.28	0.085				0.41	0.28	0.138
MVL ≥ 3 vs. MVL = 0	0.74	0.34	0.032				0.68	0.33	0.042
Braak >=3 vs. Braak< 3				0.57	0.19	0.003	0.48	0.17	0.005

^aAll models adjusted for age at enrollment, sex and education

Model 1: MVL score modeled separately

Model 2: Braak stage modeled separately

Model 3: MVL score + Braak stage modeled simultaneously