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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Bone Miner Res. 2017 Jun 26;32(9):1816–1828. doi: 10.1002/jbmr.3171

Figure 3.

Figure 3

The disruption of Rap1b in mice causes craniosynostosis. (A) Dorsal view of 2 month-old control (+/+) and Rap1b mutant (−/−) mice shows that genetic inactivation of Rap1b causes shortening of the skull. (B–C) Gross examination reveals the length of anterior frontal (AF) and inter nasal (IN) sutures affected by the Rap1b deletion at 2 months (mean, n=2). (D–G) Hematoxylin and eosin staining of the control and mutant sections evaluates synostosis phenotypes in the AF and IN sutures. Images are representatives of two independent experiments. Scale bars, 200 μm (D–G).