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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Shock. 2017 Sep;48(3):346–354. doi: 10.1097/SHK.0000000000000855

Figure 2. CDNPs reduce peritoneal bacterial loads and IL-6 levels in septic mice.

Figure 2

A) Mice were treated with 5µg CDNPs at the time of CLP induction and peritoneal bacterial loads were determined 24h later. Pooled data from 3 independent experiments with n=5-8 mice per group. B) Mice were treated with 5 µg or 10 µg PNACs, respectively, at the time of CLP induction and peritoneal concentrations of IL-6 was determined using cytometric bead assay. C) mRNA expression and D) protein secretion of IL6 by peritoneal macrophages after 24h LPS stimulation in vitro. Data are expressed as mean ± SEM. Significance was determined using Student's t-test for comparison of two samples and standard ANOVA (B) or ANOVA for repeated measurements (C and D) with Bonferroni post-hoc test for multi-comparison analysis. *p<0.05, **p<0.01, ***p<0.001.