. Author manuscript; available in PMC: 2018 Sep 1.

Published in final edited form as: J Bone Miner Res. 2017 Jun 26;32(9):1884–1892. doi: 10.1002/jbmr.3180

Table 1.

Results of backscattered images analyses in cancellous (Cn) and cortical (Ct) bone compartments from OI type V patients before treatment compared to reference data base

	Cn		Ct

	OI type V^a	Reference^b	OI type V^a	Reference^b
BMDD variables
CaMean [wt% Ca]	22.57^**** [22.11;23.06]	21.00 [20.53; 21.40]	22.18^**** [21.99; 22.42]	20.45 [19.68; 21.04]
CaPeak [wt% Ca]	23. 92^**** [23.61; 24.18]	21.66 [21.32; 22.01]	23.57^**** [23.14; 23.83]	21.14 [20.62; 21.75]
CaWidth [Δwt% Ca]	3.29 [2.99; 3.29]	3.47 [3.12; 3.64]	3.64^** [3.21; 3.73]	3.81 [3.38; 4.38]
CaLow [% B.Ar]	8.31^** [7.4; 9.22]	6.14 [4.92; 7.99]	7.63 [6.82; 9.37]	9.06 [6.22; 15.00]
CaHigh [% B.Ar]	16.13^**** [10.48; 22.01]	0.89 [0.43; 1.47]	11.85^**** [8.9; 14.28]	0.46 [0.28; 1.22]
OLS variables
OLS-porosity [%]	1.48^** [1.22; 1.75]	0.47 [0.43; 0.56]	2.29^**** [1.73; 2.44]	0.58 [0.56;0.66]
OLS-density [Nb OLS/mm²]	646.4^** [501; 800.8]	228.2 [200.7; 250]	816.5^**** [756.3; 922.5]	301.5 [262.9; 326.5]
OLS-area [μm²]	22.9 [20.7; 26.8]	21.9 [20.3; 22.6]	25.4^*** [22.3; 27.7]	20.21 [18.71; 21.75]
OLS-perimeter [μm]	20.9^** [20.4; 21.8]	19.5 [19.2; 19.9]	22.6^**** [21.3; 23.2]	18.4 [17.7; 19.6]
OLS-AR	2.83 [2.54; 3.12]	2.68 [2.44; 2.76]	2.92^** [2.75; 3.29]	2.39 [2.31; 2.6]

Data shown are median with IQ range [25%; 75%]. OI type V vs Reference (Mann Whitney):

^**

p<0.01;

^***

p<0.001;

^****

p<0.0001.

For qBEI measurement, 15 biopsy samples were evaluated (cortical n=15; cancellous n=12). For OLS analysis, the minimal bone area was achieved in 15 samples (cortical n=15; cancellous n=5).

⁽³⁸⁾. The reference OLS data for Cn and Ct were obtained from 6 control children.