Table 3.
Adjusted odds ratio (95% confidence intervals) for adverse events comparing the third vs. the first tertiles for piperacillin steady-state area under the concentration vs. time curve from zero to tau (AUCss,0-τ) and steady-state maximal concentration (Cmaxss) controlling for gestational age.
| Clinical and Laboratory AEs* | Adjusted Odds Ratio (95% CI) for Third vs. First Tertiles of AUCss,0-τ (mg*hr/L) | Adjusted Odds Ratio (95% CI) for Third vs. First Tertiles of Cmaxss (mg/L) |
|---|---|---|
| Seizures | 3.63 (0.73, 18.0) | 0.75 (0.07, 8.55) |
| Rash | 1.02 (0.14, 7.22) | 0.75 (0.12, 4.90) |
| Hypernatremia | 1.24 (0.40, 3.89) | 1.01 (0.27, 3.79) |
| Hypokalemia | 0.64 (0.28, 1.42) | 0.87 (0.39, 1.98) |
| Elevated creatinine | 0.74 (0.17, 3.20) | 0.55 (0.11, 2.81) |
| Thrombocytopenia | 1.24 (0.84, 1.83) | 1.10 (0.74, 1.65) |
| Leukopenia | 0.87 (0.51, 1.49) | 0.81 (0.46, 1.42) |
| Low hematocrit | 1.11 (0.75, 1.65) | 1.14 (0.76, 1.70) |
| Prolonged PT | 0.29 (0.06, 1.43) | 0.68 (0.21, 2.18) |
| Prolonged PTT | 0.22 (0.02, 1.90) | 0.51 (0.09, 2.92) |
| Elevated AST | 0.37 (0.04, 3.68) | 0.24 (0.03, 2.23) |
| Elevated ALT | 0.66 (0.09, 4.94) | 0.30 (0.03, 3.35) |
Adverse events, AEs; confidence intervals, CI; PT, prothrombin time; PTT, partial thromboplastin time; AST, aspartate aminotransferase; ALT, alanine transaminase
*
Please refer to Table 1 for the criteria used to determine laboratory AEs and SAEs