Table 3. Weight (Quartiles) and Risk for Incident Primary Hyperparathyroidism.

	Weight
	Q1	Q2	Q3	Q4	P-trend
Range (kg)	≤59.0	59.1-67.6	67.7-78.0	≥78.1
Median weight (kg)	54.4	63.5	72.6	87.1
Incident Cases of P-HPTH	86	99	154	152
Person-years of Follow-Up	550,126	489,747	562,766	525,429
Age-adjusted RR	Ref	1.22 (0.92, 1.63)	1.62 (1.24, 2.11)	1.68 (1.28, 2.20)	<0.001
Multivariate-adjusted Model 1 RR*	Ref	1.23 (0.92, 1.65)	1.63 (1.24, 2.14)	1.65 (1.24, 2.19)	<0.001
Multivariate-adjusted Model 2 RR**	Ref	1.25 (0.93, 1.68)	1.70 (1.29, 2.24)	1.78 (1.31, 2.40)	<0.001

^*Model 1: Multivariable model includes age, race, smoking status (past, current, never), physical activity (quintiles), menopausal status (pre or post), postmenopausal hormone use (yes or no), physical examination in prior two years, bisphosphonate use, history of hypertension, diabetes, chronic kidney disease, congestive heart failure, or osteoporosis, total vitamin D and vitamin A intake, supplemental calcium and alcohol intake, dietary intakes of calcium, magnesium, and protein, and UV-B radiation flux.

^**Model 2: Multivariable model includes adjustment for all variables in Model 1 and also predicted 25(OH)D levels

Note: Weight values for the year 2000 are shown; however weight was updated over the course of the study.