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. 2017 Feb 14;23(5):1213–1225. doi: 10.1038/mp.2017.7

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F4Cre mice show normal instrumental learning and decreased motivation in the PR7 schedule. (a) Set-up of the chambers used for operant conditioning. (b–e) There were no differences between genotypes during (b) FR1, (c) FR5, (d) extinction or (e) reinstatement (F4 n=9, F4Cre n=12). (f, g) There were no differences between genotypes in time to acquire an FR1 operant task (criteria for acquisition was 50 responses in a 45 min session) (f). Under a PR7 response schedule, genotype differences emerged at 7 days of responding, with the F4Cre animals having lower break points than the F4 mice on days 7–15 (g) (F4 n=10; F4Cre n=10) (*P<0.05, **P<0.01, ***P<0.001 and P⩾0.05, no significance). All data were presented as mean±s.e.m. FR, fixed ratio; KO, knockout.