Table 3.
No. with pneumonia | No. quasi‐cohort (person‐days) | Quasi‐rates per 1000 person‐years | Rate ratio | ||
---|---|---|---|---|---|
Crude | Adjusteda (95% CI) | ||||
Sensitivity analysis 1: excluding outcomes of hospitalization with pneumonia as secondary diagnosis | |||||
Non‐users b | 933 | 10 872 | 1.41 | 1.00 | Ref |
Current users | 268 | 1133 | 3.88 | 2.76 | 1.91 (1.56, 2.33) |
Sensitivity analysis 2: excluding last 15 days prior to index person‐moment | |||||
Non‐users b | 1662 | 18 190 | 2.41 | 1.71 | Ref |
Current users | 266 | 1085 | 6.46 | 2.68 | 1.48 (1.22, 2.78) |
Sensitivity analysis 3: classifying non‐users into past users and never users | |||||
Never users c | 1201 | 14 676 | 2.15 | 1.00 | Ref |
Past users | 314 | 2766 | 2.99 | 1.39 | 1.12 (0.96, 1.30) |
Current users | 413 | 1833 | 5.93 | 2.75 | 1.88 (1.60, 2.20) |
Sensitivity analysis 4: stratifying non‐ICS users into current and non‐current users of other respiratory medications | |||||
Non‐ICS users currently using other respiratory medications | |||||
Current users | 413 | 1833 | 3.69 | 1.82 | 1.61 (1.38, 1.89) |
Non‐users b | 1257 | 10 157 | 2.03 | Ref | Ref |
Non‐ICS users not currently using other respiratory medications | |||||
Current users | 413 | 1833 | 2.81 | 6.36 | 4.81 (3.56, 6.51) |
Non‐users b | 258 | 7285 | 0.44 | Ref | Ref |
Sensitivity analysis 5: stratifying non‐ICS users and excluding last 15 days prior to index‐person moment | |||||
Non‐ICS users currently using other respiratory medications | |||||
Current users | 214 | 969 | 3.62 | 1.67 | 1.32 (1.09, 1.60) |
Non‐users b | 1456 | 11 021 | 2.16 | Ref | Ref |
Non‐ICS users not currently using other respiratory medications | |||||
Current users | 214 | 969 | 2.49 | 6.24 | 3.07 (2.08, 4.51) |
Non‐users b | 258 | 7285 | 0.40 | Ref | Ref |
Sensitivity analysis 6: restricting asthma patients to those with three prescriptions on at least two occasions over the span of 1 year | |||||
Current users | 189 | 946 | 4.58 | 2.47 | 1.74 (1.37, 2.21) |
Non‐users b | 389 | 4801 | 1.86 | Ref | Ref |
CI, confidence interval
Adjusted for all of the factors listed in Table 1 unless otherwise indicated.
Reference group (Ref); refers to no use of ICS (fluticasone, budesonide, beclomethasone, flunisolide or triamcinolone) in the 60 days prior to the index person‐moment.
Reference group; refers to no use of ICS (fluticasone, budesonide, beclomethasone, flunisolide or triamcinolone) in the 365 days prior to the index person‐moment.