Table 1.
Trial population and demographic characteristics
| Renal impairment | |||||
|---|---|---|---|---|---|
| Demographic parameter | Healthy n = 8 | Moderate n = 8 | Severe n = 8 | All n = 16 | Total N = 24 |
| Sex, n (%) | |||||
| Male | 4 (50.0) | 5 (62.5) | 5 (62.5) | 10 (62.5) | 14 (58.3) |
| Female | 4 (50.0) | 3 (37.5) | 3 (37.5) | 6 (37.5) | 10 (41.7) |
| Ethnic origin, n (%) | |||||
| Caucasian | 8 (100) | 8 (100) | 8 (100) | 16 (100) | 24 (100) |
| Age, years | |||||
| Mean (SD) | 63.8 (3.0) | 72.5 (4.2) | 63.9 (8.5) | 68.2 (7.9) | 66.7 (6.9) |
| Median | 64.0 | 73.5 | 64.0 | 70.5 | 67.0 |
| Range | 59.0–68.0 | 64.0–76.0 | 51.0–75.0 | 51.0–76.0 | 51.0–76.0 |
| Body weight, kg | |||||
| Mean (SD) | 75.8 (8.2) | 82.5 (13.4) | 77.4 (6.1) | 79.9 (10.4) | 78.6 (9.7) |
| Median | 75.1 | 81.5 | 77.1 | 79.0 | 77.1 |
| Range (min–max) | 61.4–90.4 | 65.7–105.3 | 66.4–86.1 | 65.7–105.3 | 61.4–105.3 |
| BMI, kg/m2 | |||||
| Mean (SD) | 26.3 (3.0) | 27.2 (4.0) | 26.4 (3.1) | 26.8 (3.5) | 26.6 (3.3) |
| Median | 25.1 | 27.4 | 26.6 | 26.7 | 26.1 |
| Range (min–max) | 24.6–33.2 | 22.2–32.5 | 19.8–29.8 | 19.8–32.5 | 19.8–33.2 |
| eGFR, ml min–1 1.73m–2 | |||||
| Mean (SD) | 98.30 (6.66) | 39.85 (8.78) | 20.66 (5.11) | 30.25 (12.10) | 59.94 (34.39) |
| Median | 96.59 | 36.75 | 21.02 | 29.59 | 36.75 |
| Range (min–max) | 92.90–112.27 | 31.03–56.83 | 11.86–28.14 | 11.86–56.83 | 11.86–112.27 |
BMI, body mass index; eGFR, estimated glomerular filtration rate; max, maximum; min, minimum; SD, standard deviation.