Table 1.

S. cerevisiae and orthologous co-expression of known Protein interactions

GENE 1	GENE 2	S. cerevisiae Co-expression		Orthologous Co-expression
		correlation	p-value	D. melanogaster	C. elegans	H. sapiens	p-value
CDC28	CLB2	-0.07	0.74	*	0.77	0.59	3.7e-04
	CLB4	-0.06	0.71	0.85	0.77	0.59	1.0e-05
	CDC6	-0.03	0.60	0.77	0.32	0.37	2.6e-04
	CLB3	-0.01	0.52	0.85	0.77	0.59	1.0e-05
	CLB1	0.05	0.30	*	0.65	0.59	7.3e-04
	CLB5	0.06	0.27	0.87	0.65	0.45	3. 0e-05
DMC1	PDC5	-0.09	0.80	0.59	*	0.17	6.8e-03
	PDC1	-0.05	0.67	0.59	*	0.17	6.8e-03
	RIS1	-0.02	0.56	*	0.34	0.52	4.3e-03
PRP9	RIS1	0.02	0.41	*	0.28	0.62	3.7e-03
	PRP11	0.05	0.30	0.88	0.35	0.33	1.6e-04
	NOG2	0.07	0.24	0.41	0.33	0.66	3.5e-04
SSN6	CUS1	-0.06	0.71	0.76	0.32	*	5.4e-04
	SNP1	0.08	0.21	0.79	0.21	*	2.1e-03
PAB1	SGN1	-0.17	0.93	0.56	0.19	0.26	2.4e-03
	RNA14	-0.06	0.71	0.42	0.17	0.24	5.8e-03
PFS2	RNA14	-0.03	0.60	0.44	0.31	-	8.5e-03
HAT1	HAT2	-0.04	0.33	0.86	0.19	0.22	7.3e-04
SIT4	TAP42	-0.16	0.92	0.54	-	0.36	4.3e-03
TRS23	BET3	-0.10	0.82	*	0.20	0.52	8.1e-03
DNA2	RAD27	-0.01	0.52	*	0.41	0.47	3.9e-03
PRP8	SNU114	0.05	0.30	*	0.60	0.57	8.7e-04
HRB1	MTR10	-0.07	0.74	0.56	0.27	0.27	1.5e-03
BTT1	EGD2	-0.08	0.77	0.42	0.52	0.59	2.0e-04
GPA1	STE11	0.07	0.24	0.55	0.25	0.37	1.1e-03
UBA2	AOS1	0.08	0.21	0.74	0.17	0.41	5.4e-04
SPT15	BRF1	0.09	0.19	0.72	0.21	0.23	1.1e-03
TAF5	TAF9	0.05	0.30	0.86	-	0.18	2.1e-03
LSM5	KEM1	0.04	0.33	-	0.37	0.65	2.3e-03
RPB3	MED7	0.01	0.45	*	0.49	0.32	5.3e-3

* denotes that at least one of the corresponding orthologs did not have expression data.

- denotes that there is no pair of corresponding orthologs.