Table 7.
Non-synonymous Changes on the 1A3/1A4 Branch
| Site* | Nucleotide Changes/Site | Hominoid SULT1A Ancestor | Hominoid SULT1A3 Ancestor | |||||
| Residue | PP† | Physicochemical Properties | Residue | PP | Physicochemical Properties | |||
| 44 | 1 | Ser | (1.00) | tiny polar | → | Asn | (1.00) | small polar |
| 71 | 1 | His | (0.99) | non-polar aromatic positive | → | Asn | (1.00) | small polar |
| 76 | 1 | Phe | (1.00) | non-polar aromatic | → | Tyr | (1.00) | aromatic |
| 77 | 2 | Met | (0.99) | non-polar | → | Val | (1.00) | small non-polar aliphatic |
| 84 | 1 | Phe | (1.00) | non-polar aromatic | → | Val | (1.00) | small non-polar aliphatic |
| 85 | 1 | Lys | (1.00) | Positive | → | Asn | (1.00) | small polar |
| 86 | 2 | Val | (0.98) | small non-polar aliphatic | → | Asp | (1.00) | small polar negative |
| 89 | 3 | Ile | (0.98) | non-polar aliphatic | → | Glu | (1.00) | polar negative |
| 93 | 1 | Met | (0.00) | non-polar | → | Leu | (1.00) | non-polar aliphatic |
| 101 | 1 | Ala | (1.00) | tiny non-polar | → | Pro | (1.00) | small |
| 105 | 1 | Leu | (1.00) | non-polar aliphatic | → | Ile | (1.00) | son-polar aliphatic |
| 107 | 1 | Thr | (1.00) | tiny polar | → | Ser | (1.00) | tiny polar |
| 132 | 1 | Ala | (1.00) | tiny non-polar | → | Pro | (1.00) | small |
| 143 | 1 | Tyr | (1.00) | aromatic | → | His | (1.00) | non-polar aromatic positive |
| 144 | 2 | His | (0.99) | non-polar aromatic positive | → | Arg | (1.00) | polar positive |
| 146 | 2 | Ala | (1.00) | tiny non-polar | → | Glu | (1.00) | polar negative |
| 148 | 1 | Val | (1.00) | small non-polar aliphatic | → | Ala | (1.00) | tiny non-polar |
| 222 | 1 | Leu | (0.99) | non-polar aliphatic | → | Phe | (1.00) | non-polar aromatic |
* Sites underlined were identified as being positively selected using the branch-site specific models. †Posterior probabilities that the ancestral residues are correct, conditional on the model of sequence evolution used.