Table 1.
Variables determining oxygenation and lung mechanics in saline controls and LPS-challenged animals
| Parameter | Group | Time (h) | ||||
|---|---|---|---|---|---|---|
| Baseline | −3 h | −2 h | −1 h | T0 | ||
| PaO2/FiO2 (mmHg) | NS | 466 ± 26 | 458 ± 60 | 531 ± 51 | 509 ± 60 | 479 ± 34 |
| LPS | 440 ± 19 | 312 ± 51 | 242 ± 36*** | 194 ± 10*** | 157 ± 23*** | |
| PaCO2 (mmHg) | NS | 35.2 ± 2.8 | 30.8 ± 2.8 | 30.5 ± 1.8 | 32.3 ± 1.1 | 31.8 ± 1.49 |
| LPS | 36.8 ± 2.4 | 30.2 ± 1.8 | 37.5 ± 1.5 | 36.5 ± 3.0 | 44.7 ± 5.0** | |
| AaDO2 (mmHg) | NS | 47 ± 7 | 48 ± 14 | 52 ± 1 | 51 ± 12 | 60 ± 4 |
| LPS | 63 ± 5 | 124 ± 20 | 143 ± 15** | 213 ± 53** | 224 ± 48** | |
| PAWPeak (mbar) | NS | 16.5 ± 1.8 | 16.5 ± 1.5 | 16.5 ± 1.7 | 17.3 ± 2.0 | 17.3 ± 1.8 |
| LPS | 21.3 ± 0.9 | 27.2 ± 1.8** | 30.2 ± 2.4*** | 31.2 ± 2.4*** | 35.7 ± 2.5*** | |
| PAWPlateau (mbar) | NS | 12.2 ± 1.8 | 11.5 ± 1.7 | 12.2 ± 2.0 | 13.2 ± 2.3 | 13.8 ± 2.2 |
| LPS | 15.3 ± 1.2 | 18.8 ± 1.4 | 22.3 ± 2.3** | 25.7 ± 2.5*** | 27.3 ± 3.2*** | |
| Resistance (mbar/l/s) | NS | 9.3 ± 1.4 | 7.9 ± 1.2 | 8.1 ± 1.3 | 7.5 ± 1.1 | 8.1 ± 1.3 |
| LPS | 8.5 ± 0.4 | 13.6 ± 2.5 | 15.7 ± 3.5 | 15.1 ± 3.2 | 14.7 ± 2.2 | |
| Compliance (ml/mbar) | NS | 31.2 ± 3.5 | 33.3 ± 3.0 | 34.5 ± 4.0 | 35.6 ± 4.3 | 32.8 ± 3.3 |
| LPS | 28.2 ± 2.7 | 23.0 ± 2.1 | 21.4 ± 2.3* | 20.7 ± 2.9** | 16.7 ± 1.8** | |
Oxygenation and ventilation parameters in saline control and LPS challenge animals at baseline and a series of time points until the end of the experiment when ALI model was diagnosed (data shown are mean ± SEM, N = 6 of each group; *P < 0.05; **P < 0.01; ***P < 0.001 versus control group). PaO2, oxygen partial pressure; FiO2, inspiratory oxygen fraction; PaCO2, carbon dioxide partial pressure; PAWPeak, peak airway pressure; PAWPlateau, plateau airway pressure