Table 2.
Systemic and pulmonary hemodynamic measurements in saline controls and LPS-challenged animals
| Parameter | Group | Time (h) | ||||
|---|---|---|---|---|---|---|
| Baseline | −3 h | −2 h | −1 h | T0 | ||
| CO (l/min) | NS | 4.1 ± 0.3 | 4.5 ± 0.4 | 4.1 ± 0.4 | 4.2 ± 0.4 | 4.2 ± 0.4 |
| LPS | 4.1 ± 0.3 | 4.1 ± 0.5 | 5.1 ± 0.3 | 5.0 ± 0.3 | 3.4 ± 0.3 | |
| MAP (mmHg) | NS | 105 ± 6 | 98 ± 6 | 102 ± 8 | 101 ± 7 | 102 ± 8 |
| LPS | 113 ± 3 | 78 ± 8 | 56 ± 4*** | 57 ± 5*** | 54 ± 5*** | |
| SVRI (dyn s/cm5/m2) | NS | 1783 ± 198 | 1810 ± 169 | 1927 ± 148 | 1822 ± 183 | 1909 ± 218 |
| LPS | 2399 ± 238 | 1987 ± 217 | 1002 ± 111** | 952 ± 56** | 1160 ± 97* | |
| mPAP (mmHg) | NS | 16.5 ± 1.0 | 16.7 ± 0.5 | 15.7 ± 1.2 | 17.8 ± 1.5 | 18.5 ± 1.2 |
| LPS | 18.8 ± 1.5 | 28.8 ± 1.9*** | 3.3 ± 2.0*** | 34.7 ± 2.7*** | 41.0 ± 1.7*** | |
| PVRI (dyn s/cm5/m2) | NS | 204 ± 20 | 193 ± 16 | 231 ± 48 | 209 ± 35 | 201 ± 13 |
| LPS | 364 ± 40 | 552 ± 115*** | 542 ± 67** | 634 ± 120*** | 781 ± 74*** | |
| PAWP (mmHg) | NS | 6.0 ± 1.2 | 6.5 ± 1.5 | 6.3 ± 1.4 | 6.8 ± 1.5 | 6.8 ± 1.2 |
| LPS | 4.0 ± 1.2 | 5.5 ± 0.6 | 8.0 ± 0.6 | 9.0 ± 0.9 | 12.2 ± 1.4* | |
| EVLWI (ml/kg) | NS | 9.0 ± 0.5 | 9.7 ± 0.9 | 9.3 ± 0.5 | 9.5 ± 0.6 | 10.0 ± 0.9 |
| LPS | 8.0 ± 0.5 | 9.7 ± 0.7 | 9.8 ± 0.9 | 11.0 ± 0.8 | 15.4 ± 1.3*** | |
| PVPI | NS | 2.7 ± 0.1 | 2.8 ± 0.3 | 3.0 ± 0.3 | 3.0 ± 0.3 | 2.9 ± 0.2 |
| LPS | 2.7 ± 0.2 | 3.6 ± 0.3 | 4.0 ± 0.7 | 4.6 ± 0.7 | 5.6 ± 0.5*** | |
Hemodynamic parameters are compared between the saline control and LPS-challenged group. (Data are mean ± SEM, N = 6 of each group; *P < 0.05, **P < 0.01, ***P < 0.001; versus control group)
CO cardiac output, MAP mean arterial pressure, SVRI systemic vascular resistance index, MPAP mean pulmonary arterial pressure, PVRI pulmonary vascular resistance index, PAWP pulmonary artery wedge pressure, EVLWI extravascular lung water index, PVPI pulmonary vascular permeability index