Table 3.

Variables determining oxygenation and lung mechanics in LPS + HA (sham)- and LPS + HA-treated animals

Parameter	Group	Time (h)
		Baseline	T0	2 h	4 h	6 h	8 h
PaO2/FiO2 (mmHg)	LPS + HA (sham)	329 ± 55	164 ± 10†	131 ± 20†	129 ± 21†	178 ± 68	169 ± 53
	LPS + HA	387 ± 10	183 ± 6†	254 ± 44*	211 ± 31†	264 ± 31	315 ± 22*§
PaCO2 (mmHg)	LPS + HA (sham)	45 ± 4	40 ± 7	45 ± 17	46 ± 14	46 ± 16	42 ± 14
	LPS + HA	37 ± 5	53 ± 6†	59 ± 9†	54 ± 3†	51 ± 2	45 ± 3
AaDO2 (mmHg)	LPS + HA (sham)	96 ± 24	170 ± 6	363 ± 129	330 ± 103	371 ± 102†	358 ± 96
	LPS + HA	79 ± 10	172 ± 29†	368 ± 68†	368 ± 77†	334 ± 81†	296 ± 66†
PAWPeak (mbar)	LPS + HA (sham)	17.7 ± 1.8	32.0 ± 2.6†	29.7 ± 5.2†	29.7 ± 2.7†	28.3 ± 1.7†	26.7 ± 3.2
	LPS + HA	18.9 ± 1.5	29.0 ± 1.0†	26.3 ± 1.9†	26.3 ± 1.8†	24.7 ± 1.8	24.3 ± 2.3
PAWPlateau (mbar)	LPS + HA (sham)	13.3 ± 0.9	21.0 ± 1.0†	22.7 ± 2.9†	23.3 ± 2.4†	21.0 ± 1.0†	21.7 ± 0.9†
	LPS + HA	15.3 ± 1.8	24.7 ± 1.3†	22.0 ± 1.2†	21.0 ± 1.0†§	20.3 ± 0.9†§	19.0 ± 0.0*†§
Resistance (mbar/l/s)	LPS + HA (sham)	8.0 ± 1.1	15.0 ± 1.8	17.5 ± 4.6	13.4 ± 3.9	13.7 ± 3.6	13.3 ± 4.0
	LPS + HA	8.2 ± 1.0	11.7 ± 1.8	8.8 ± 1.5	8.7 ± 1.2	8.0 ± 1.1	7.2 ± 1.2§
Compliance (ml/mbar)	LPS + HA (sham)	32.6 ± 2.9	20.1 ± 6.1	19.6 ± 7.7	20.2 ± 6.0	20.6 ± 5.0	21.1 ± 5.9
	LPS + HA	27.1 ± 2.9	19 ± 2.2†	20.1 ± 1.1	22.5 ± 2.0	22.7 ± 2.8	23.3 ± 2.3

Oxygenation and ventilation parameters in LPS + HA (sham)- and LPS + HA-treated animals at baseline and a series of time points until the end of the experiment (data are mean ± SEM, N = 3–4 of each group; *P < 0.05 when compared between groups; ^† P < 0.05 when compared with baseline within per group; ^§ P < 0.05 versus T0 within per group). PaO₂, oxygen partial pressure; FiO₂, inspiratory oxygen fraction; PaCO₂, carbon dioxide partial pressure; P_AWPeak, peak airway pressure; P_AWPlateau, plateau airway pressure