Table 5.

Ontology groups and associated differentially expressed plasma proteins in the time points of T0 and 8 h after HA-sham treatment versus baseline

GO biological process	Accession	Protein name	Fold change over baselinea
			T0/baseline	8 h/baseline
Acute-phase response/acute inflammatory response	P79263	Inter-alpha-trypsin inhibitor heavy chain H4	1.22	2.17
	F1SH92	Inter-alpha-trypsin inhibitor heavy chain H4	1.39	2.04
	Q29056	Interleukin-1 receptor antagonist protein	1.49	1.51
	F1SFI7	Alpha-2-HS-glycoprotein (Fragment)	0.76	0.49
	Q29014	Alpha-1 acid glycoprotein (Fragment)	0.68	0.49
	Q8SPS7	Haptoglobin	0.74	0.57
	Q6S4N2	Heat shock 70 kDa protein 1B	0.64	0.65
Regulation of immune system process	P01025	Complement C3	1.45	0.88
	A5PF00	B-factor, properdin	0.75	0.62
	F1RMN7	Hemopexin	0.70	0.63
	Q69DL4	Complement C1qB (Fragment)	0.81	0.60
	A0SEH0	Complement component C6	0.71	0.76
	Q29041	Ficolin-2	0.75	0.69
Defense response/response to stress	P52552	Peroxiredoxin-2 (Fragment)	1.28	1.30
	P32195	Protegrin-2	4.76	2.43
	O02705	Heat shock protein HSP 90-alpha	1.37	2.56
	Q6QR67	Resistin	5.00	3.06
Proteolysis	C9VZX4	Matrix metallopeptidase 1	1.79	3.98
	C9VZX5	Matrix metallopeptidase 10	1.13	1.53
	F2Z528	Proteasome subunit alpha type	1.22	1.22
	F2Z5K2	Proteasome subunit alpha type	1.28	1.21
	I3LQ51	Proteasome subunit beta type	1.49	1.50
	P03974	Transitional endoplasmic reticulum ATPase	1.35	2.27
	Q9GMA6	Alpha-1-antichymotrypsin 2	0.81	0.55
	C4PGL9	Mannan-binding lectin serine peptidase 2	0.79	0.97
	F1SCF0	Alpha-1-antitrypsin	0.81	0.66
Coagulation	F1RPW2	Coagulation factor V	0.66	0.45
	F1RZ36	Coagulation factor VIII	0.64	0.74
	O97507	Coagulation factor XII	0.76	0.66
	K7GQL2	Coagulation factor XIII, A1 polypeptide	0.71	0.79
	F1RX36	Fibrinogen alpha chain	0.83	1.11
	P14460	Fibrinogen alpha chain (Fragment)	1.47	3.12
	P14477	Fibrinogen beta chain (fragment)	1.39	2.30
	P06867	Plasminogen	0.77	0.57
	F1SB81	Plasminogen	0.59	0.59
	B3STX9	Prothrombin	0.68	0.76
Negative regulation of blood coagulation	I3LRJ4	Vitamin K-dependent protein C	0.69	0.57
Metabolic process	Q29214	60S acidic ribosomal protein P0	1.47	2.45
	F1RYZ0	60S acidic ribosomal protein P2	2.17	4.72
	P01965	Hemoglobin subunit alpha	1.39	0.68
	F1RII7	Hemoglobin subunit beta	1.28	0.74
	A0SNU7	Glyceraldehyde-3-phosphate dehydrogenase (fragment)	1.23	1.41
	G9F6X8	Prolyl 4-hydroxylase beta polypeptide	1.45	2.14
	F1SN27	Sorbitol dehydrogenase	1.67	3.13
Regulation of lipid storage	Q2LE37	Apolipoprotein M	1.25	1.02
	Q29248	Apolipoprotein A-I (Fragment)	0.79	0.79
Cellular metal ion homeostasis	Q8WMN8	Lactoferrin (Fragment)	1.64	0.93
	P09571	Serotransferrin	0.77	0.63
Transport	P04404	Chromogranin-A (Fragment)	1.75	1.89
	Q29545	Inhibitor of carbonic anhydrase	0.67	0.54
	A4US67	Paraoxonase	0.75	0.67
	F1RUN2	Serum albumin	0.76	0.60
	P50390	Transthyretin	0.81	0.76
Positive regulation of cell differentiation	Q0PM28	Pigment epithelium-derived factor	0.70	0.84
Multicellular organismal process	P00761	Trypsin	0.78	0.55
Response to unfolded protein	F1RS36	78 kDa glucose-regulated protein	1.33	1.38
Cytoskeleton organization	I3LVD5	Actin, cytoplasmic 1	1.64	1.09
	A0A0B8RSX6	Filamin A, alpha	1.45	1.71
	B6VNT8	Cardiac muscle alpha actin 1	1.82	1.39
	Q6QA25	Tropomyosin 3	1.59	1.91
	P67937	Tropomyosin alpha-4 chain	1.23	1.29
	Q767L7	Tubulin beta chain	1.37	0.84
	P02543	Vimentin	1.54	5.13
Obsolete GTP catabolic process	Q0PY11	Elongation factor 1-alpha	1.35	1.37
Chromosome organization	P62802	Histone H4	2.50	1.87
Tissue remodeling	Q711S8	Secreted phosphoprotein 24	0.82	0.79
Regulation of biological process	F1S682	Sulfhydryl oxidase	0.80	0.86

^aNote that changes are expressed as relative abundance of the plasma proteins at T0 or 8 h after HA-sham treatment compared with baseline within the LPS + HA (sham) group. A fold change ≥ 1.20, p < 0.05 represents more protein abundance in T0 or 8 h versus baseline. By contrast, a fold change ≤ 0.83, p < 0.05 represents less protein abundance in T0 or 8 h versus baseline