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. 2017 Aug 14;7:8102. doi: 10.1038/s41598-017-08733-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic conceptual representation of INPs in Gallus gallus. The variables determining the existence of INPs are represented around each bird. The size of the variable indicates if the animals show high or low response in each of the parameters. SSR: skin-swelling response to PHA-P; Ab SRBC: antibody response against SRBC; Inn/Acq: innate/acquired leukocyte ratio; level of expression of pro-inflammatory (IFN-γ) and anti-inflammatory (IL-4) mediators. ‘FISCHER-like’ hens with high CORT concentration also manifest high Innate/Acquired and Ab SRBC, but low SSR, IFN-γ and IL-4 levels. ‘LEWIS-like’ counterparts have low CORT as well as low Innate/Acquired and AB SRBC responses, but high SSR, as well as INE mediators (IFN-γ and IL-4) response.