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. 2017 Aug 14;7:8094. doi: 10.1038/s41598-017-06904-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of Ikk2 caused hemorrhage. (A,B) Bright-field images of wild-type and ikk2 ^−/− (zygotic) embryos obtained from heterozygotic parents at 48 hpf. Red arrows - the hemorrhage site. (A,A′) Ventral view. (B,B′) dorsal view. (C) Quantification of hemorrhaging embryos. (D) Quantification of embryos with cranial hemorrhage vs that in other parts of the body. (C,D) Unpaired Student’s t test. (E,F) Confocal Z-projection shows wild type (E) and ikk2 ^−/− (F) embryos of the Tg(fli:EGFP)/Tg(gata:DsRed) background at 48 hpf. (E′,F′) Confocal Z-projection shows Tg(fli:EGFP) embryos without the dorsal most MtA, MsA and DLV. EGFP was pseudo-colored as black. PHBC (blue), BA (red), and CtAs (purple) were marked. * - the affected CtAs with cranial hemorrhage in (F). All data expressed as mean ± SEM; scale bar in all panels: 100 μm. Abbreviations – PHBC: primordial hindbrain channels; BA: basilar artery; CtAs: central arteries (51).