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. 2017 Aug 14;7:8024. doi: 10.1038/s41598-017-08603-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Muscle biopsy analysis. (a) Description of bioinformatics analysis pathway, (b) Muscle histology where A-C shows normal muscle tissue from one of the controls. D-F shows classical features of IBM in one of the biopsies. G–I are sections from a muscle biopsy from one of the patients with Jo-1 myositis. A,D and G were stained with HE and B,E and H with modified Gomori trichrome. C,F and I were immunolabelled for β₂-microglobulin. Inset in F shows inclusions immunolabelled for ubiquitin. The scale bar represents 50 μm, (c) Principle component analysis (PCA) of the mRNA data from control, IBM and Jo-1 myositis, (d) Non-supervised hierarchical cluster analysis of the mRNA data from control, IBM and Jo-1 myositis.