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. 2017 Aug 14;7:8002. doi: 10.1038/s41598-017-07422-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time series simulation of fractional killing. Panels A and C show the absolute levels of p53, while panels B and D show the time integrated levels. (A and B) A total of 300 cells are subjected to a low level of drug (drug = 0.45), about half of the cells in the population quickly activate p53 and undergo apoptosis (red curves in A and B). In the remaining cells, p53 is slowly activated and these cells survive (blue curves in A and B). (C and D) When a population of 300 cells are treated with a high level of drug (drug = 1), a higher percentage of cells activate their p53 fast and undergo apoptosis (red curves in C and D).