Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Aug 14;7:8002. doi: 10.1038/s41598-017-07422-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

New strategies designed to combat fractional killing. (A) Time series simulations with a population of cells treated with cisplatin, a CIAP inhibitor, and a BCL inhibitor. (B) Inhibition of BCL expands the area corresponding to apoptosis; while inhibition of CIAP keeps the time dependent trajectories of the cells at the bottom of the plane. (C) The black solid curve and the red solid curve indicate the BAXm activation threshold before and after Caspase8 activation, respectively. The area at the right of the BAXm activation threshold curve defines the apoptosis area. Hence, the activation of Caspase8 expands the area of apoptosis. (D) Time series simulations with a population of cells treated with cisplatin and a Caspase8 activator.