Skip to main content
. 2017 Aug 14;7:8002. doi: 10.1038/s41598-017-07422-2

Table 2.

List of strategies that combat fractional killing.

Strategy Experimental result Theoretical category*
Increasing drug concentration Observed CT
CIAP inhibition Observed CT
BCL inhibition Observed BG
Nutlin Observed CT
Inhibition of both CIAP and BCL Prediction AB
Caspase8 activation Prediction BG

*Three categories:

1. BG- alteration of bifurcation geometry;

2. CT- alteration of cellular trajectory;

3. AB- alteration of both bifurcation geometry and cellular trajectory.