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. 2017 Aug 14;7:8066. doi: 10.1038/s41598-017-08559-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Simplified scheme of the enzymes and transcription factors involved in de novo lipogenesis pathway. Briefly, the enzymes Acetyl-CoA Carboxylase alpha (Acaca), Fatty acid synthase (Fasn), Elongation of very long chain fatty acids protein 6, (Elovl6), and Stearoyl-CoenzimeA desaturase, (Scd1) participate directly in the synthesis and elongation of fatty acids starting from Acetyl-CoA. Liver X receptor regulates the transcription of Sterol regulatory element-binding factor 1, (Srebf1), which in turn, stimulates the transcription of the enzymes mentioned above to increase the lipid biosynthesis in the liver. Peroxisome proliferator-activated receptor gamma (Pparg), a master regulator of transcription, also affects the expression level of the proteins in the de novo lipogenesis process. In the figure the molecules studied in this research has been highlighted by bold letters in a square. The blue letters are the changes occurring in the maternal liver. In red are the changes found in fetal livers.