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. 2017 Aug 14;7:8077. doi: 10.1038/s41598-017-07560-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Figure-6 — The migration, invasion and proliferation capacities of JEG3 cells are suppressed by HIF1α knockdown in cells exposed to 3% O₂. (A,B) Real-time PCR and western blot analyses showing the specific knockdown of HIF1α in JEG3 cells by siRNA. (C) The migration and invasion capacities of JEG3 cells transfected with scramble (control) siRNA or HIF1α siRNA. (D) The number of migrated or invaded cells was counted and the quantitative data are expressed as the fold change from the control of three independent experiments. (*P < 0.05, **P < 0.01, Student’s t-test) (E) The proliferation capacity of JEG3 cells with transfected with scramble (control) siRNA or HIF1α siRNA for 48 h. (not significant, Student’s t-test).